Education and Professional Training
|Residency in Obstetrics and Gynecology||2015 – present|
|University of Iowa Hospitals and Clinics|
|Doctor of Osteopathic Medicine||May 2015|
|Chicago College of Osteopathic Medicine||May 2015|
|Doctor of Philosophy in Molecular and Cellular Biology||May 2013|
|University of Iowa|
|Bachelor of Science in Biological Sciences with a Minor in Psychology||May 2005|
|University of Iowa|
Formal Research Experience
|2015||Graduate Thesis Research
Program in Molecular and Cellular Biology, The University of Iowa College of Medicine
Mentor: Frederick Domann, Ph.D.
|2008 – 2009||Doris Duke Research Fellow
Doris Duke Research Fellow Program, The University of Iowa Hospitals and Clinics
Mentor: Raymond Hohl, M.D., Ph.D.
|2007||Summer Medical Student Research Fellow
Children’s Memorial Hospital, Northwestern University and Midwestern University
Mentors: Lon Van Winkle, Ph.D. and Philip Iannaccone, M.D., Ph.D.
|2005 – 2006||Research Assistant I
Department of Pharmacology, The University of Iowa College of Medicine
Mentor: Nancy Lill, Ph.D.
|2003||Undergraduate Summer Research Fellow
Pharmacology Undergraduate Research Program, The University of Iowa College of Medicine
Mentor: Nancy Lill, Ph.D.
Honors, Awards and Fellowships
|2017||Maternal Fetal Medicine Resident Award, University of Iowa MFM Division|
|2013||Outstanding Poster Award, University of Iowa Health Sciences Research Week|
|2012||Outstanding Poster Award, American Osteopathic Medical Association National Research Conference|
|2012||Student Research Fellowship, National Student Osteopathic Medical Association|
|2012||Seed Grant Recipient, American Medical Association Foundation|
|2011||TL-1 Linked Training Award (Full Graduate Stipend), Institute for Clinical and Translational Medicine|
|2010||Graduate Student Senate Travel Award, University of Iowa Graduate Student Senate|
|2010||Young Investigator’s Award, National Society for Free Radical Biology and Medicine|
|2008||Doris Duke Clinical Research Fellowship, University of Iowa|
|2008||Basic Science Award in Biochemistry, Midwestern University Class of 2010|
|2007||Summer Medical Student Research Fellowship, Midwestern University/CCOM|
|2004||Outstanding Poster Award, University of Iowa Biosciences Poster Competition|
|2004||Travel Award, American Society of Biochemistry and Molecular Biology Annual National Meeting|
|2003||Summer Undergraduate Research Fellowship, University of Iowa Department of Pharmacology|
Professional Societies and Service Committees
|2013 – Present||Grant Reviewer – American Medical Association Foundation Seed Grant Committee|
|2014 – Present||Member – American Congress of Obstetricians and Gynecologists|
|2015||Official Reviewer – Journal of Oxidative Medicine and Cellular Longevity|
|2015||Official Reviewer – PLoS ONE|
|2006 – 2013||Member – American Osteopathic Association|
|2009 – 2013||Member – Society for Free Radical Biology and Medicine|
Service and Extracurricular
|2012 – 2015||Volunteer patient examiner, Chicago Community Health Clinic|
|2009 – 2013||Volunteer patient examiner, Iowa City Free Medical Clinic|
|2008 – 2009||Volunteer patient guide, Iowa City Free Medical Clinic|
|2007 – 2008||President and founder, CCOM Research Club|
- Place, T. L., Domann, F.E., Case, AJ. Limitations of Oxygen Delivery to Cells in Culture: An Underappreciated Problem in Basic and Translational Research. Free Radical Biology and Medicine. 113:311-322 (2017).
- Place, T. L. & Mezhir, J. J. Minimally Invasive Approaches to Resection for Pancreatic Adenocarcinoma: An Evidence Based Literature Review. J Gastrointest Surg. 19(2):375-86 (2015)
- Place, T. L. et al. A Novel Role for Prolyl-hydroxylase 3 in Epithelial-to-Mesenchymal Transition. PLoS ONE 8(12):e83021 (2013).
- Place, T. L. & Domann, F.E. Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein. Hypoxia. I, 13-27 (2013).
- Place, T. L. & Mezhir, J. J. Molecular Characterization of Desmoid Tumors: Decryption of the Enigma. Onkologie 35:641-642 (2012).
- Place, T. L. et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE 6(1):e14617 (2011).
- Visser Smit, G. D. Place, T. L. (co-first author) et al. Cbl controls EGFR fate by regulating early endosome fusion. Science Signaling. 2(102):ra86 (2009).
- Cao, X. R, Place, T. L. et al. Nedd4 controls animal growth by regulating IGF-I signaling. Science Signaling 1:ra5 (2008).
- Stern, K. A., Place, T. L. & Lill, N. L. EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate. Biochem J 410, 585-594 (2008).
- Stern, K. A. Place, T. L. et al. Epidermal growth factor receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation. Molecular and Cellular Biology 27,888-898 (2007).
Selected Oral Research Presentations
- Trenton L. Place. A Novel Role for Prolyl-Hydroxylase 3 Gene Silencing in Epithelial to Mesenchymal-Like Transition. Biochemistry Departmental Seminar, 2012. Midwestern University. Invited Speaker.
- Trenton L. Place, James J. Mezhir, Frederick Domann. Prolyl-hydroxylase 3 silencing correlates with epithelial to mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma. American College of Surgeons Clinical Congress 2012. Chicago, IL. Oral Presentation.
- Trenton L. Place, James J. Mezhir, Frederick Domann. HIF Prolyl-hydroxylase 3 Silencing Correlates With a Mesenchymal Transcriptional Program in Human Pancreatic Cancer Cells. CTSA National Meeting 2012, Mayo Clinic. Oral Presentation.
- Trenton L. Place, James J. Mezhir, Frederick Domann. HlF Prolyl-hydroxylase 3 Silencing Correlates With a Mesenchymal Transcriptional Program in Human Pancreatic Cancer Cells. University of Iowa Jakobson Conference, 2012. Oral Presentation.
Selected Research Poster Presentations
- Trenton L. Place and Frederick E. Domann. Actin Proline Hydroxylation: Discovery of a Novel Actin Post-Translational Modification and Implications for the Effects of Hypoxia on Tumor Metastasis. CTSA National Meeting 2013, Mayo Clinic. Poster Presentation
- Trenton L. Place, James 1. Mezhir, Frederick Domann. HIF Prolyl-hydroxylase-3 plays a key role in Epithelial to Mesenchymal Transition. Osteopathic Medical Conference 2012, San Diego, CA. Poster
- Trenton L. Place, Sujatha Venkataraman, Matthew P. Fitzgerald, Sabine Von’ink, Adam 1. Case, Melissa L.T. Teoh, and Frederick E. Domann. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. FRBM Conference. Orlando, Fl. November 2010. Poster
- Trenton Place, Dave Schmitz, Lenore Pitstick, AI Campione, Lon Van Winkle. Glutamate and C-myc: Interplay for the Growth and Maintenance of Pluirpotent Human Embryonic Stem Cells? Midwestern University Research Day, Poster Presentation, Midwestern University, May 2008. Poster
- Nancy L. Lill, Gina D. Visser Smit, Trenton L. Place, and Kathryn A. Stern. The Cbl RING Finger Tail Regulates Sorting of Endosome Fusion. Keystone Symposia, Big Sky, Montana, January 12-17, 2008. Poster
- Nancy Lill, Kathryn Stern, Gina Visser, Trenton Place. Cbl Regulates EGF Receptor Fate at Two Endocytic Trafficking Checkpoints. Experimental Biology, San Francisco, CA, April 1-5, 2006. Poster
- Trenton Place, Gina Visser, Kathryn Stern, Nancy Lill. Cbl RF-tail Residues Control EGF-R Fate at Two Distinct Endocytic Trafficking Checkpoints. University of Iowa Research Week 2006, University of Iowa, March 29-30, 2006. Poster
- Trenton Place, Kathryn Stem, Nancy Lill. Mapping the Site of Hrs Regulation by Cbl. University of Iowa Biosciences Undergraduate Poster Competition, University of Iowa, September 1, 2004. Poster
- Trenton Place, Kathryn Stern, Nancy Lill. Mapping the Site of Hrs Regulation by Cbl. American Society for Biochemistry and Molecular Biology, Boston, MA, June 15, 2004. Poster
- Kathryn Stern, Trenton Place, Gina Visser, Nancy Lill. Regulation of Hrs posttranslational modification by Cbl. American Society for Biochemistry and Molecular Biology, Boston, MA, June 14 2004. Poster